Increasing the Prediction Power of Preterm Labor using Interleukin 6 and Fetal Fibronectin as Alarming Signals in Symptomatic Patients

Background: Giving birth at preterm is considered as a bothering problem to both healthcare systems and pregnant women around the world, causing alarming levels of mortality. To avoid this issue, certain biological markers can be employed for early detection predict occurrence PTD (PTD) ahead time giving better medical care who risk PTD.
 Objective: The current study was performed evaluate power using interleukin-6 (IL-6) fetal fibronectin (fFN) present in cervicovaginal fluid (CVF) predictors symptomatic patients.
 Patients & Methods: In study, 91 hospital attendees (24-34 weeks; 18-45 years old) with suggested symptoms, such abdominal pain uterine contraction cervical length less than 25mm, were participated. detect IL-6 fFN, vaginal swabs collected performing an ELISA test later follow up patients within 48hrs, seven days, 14 days from first day admission hospital.
 Results: No significant association between age, parity, BMI, gestational but previous history PTD. There increase level CVF fFN best cut-off value is(>45ng/ml) (95%CI 0.763-0.918) accuracy 85.2% sensitivity 73.1% specificity 95.6% which high (P≤0.01).While (>231pg/ml) (95% CI 0.630- 0.820), 73.3%, 50% 96.9% statistically finding (P≤0.01).The predictive combined labor 84.6% 84.6%,specificity 92.3%, positive (PPV) 81.5%, negative 93.8% 90.1%.
 Conclusion: Each or located may provide strong predictor PTD; however, prediction capability even stronger signal detecting if biomarkers requested same time.